specified its significant job in immunity, It's not shocking that excess MIF expression has actually been associated with exaggerated inflammation and immunopathology. Moreover, MIF demonstrates nicely-documented proliferative Homes. MIF is secreted by lots of differing types of cells and interacts with several receptors, which helps to explain The variability of biological features. Receptors that interact that bind MIF include things like CD74, and chemokine receptors CXCR2 and CXCR4 (7–fifteen).

Neutrophils appear to Enjoy a significant function in tissue problems and the development of acute lung injury (seventy five). it is crucial to mention that extra MIF was revealed to correlate with neutrophil accumulation in the lung (76). even so, it remains unclear the amount MIF-CXCR2 interaction is contributing to leukocyte recruitment.

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Subsequently, a developing overall body of evidence supported the thought that CD74 could have supplemental features as being a receptor. area expression of CD74 transpired independently of concomitant MHCII expression.

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Structural characteristics of MIF make this cytokine ideal for compact-molecule antagonism in rheumatic illnesses.

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